Unlock information on 400+ supplements and 600+ health topics. Milk thistle (MT) is an annual or biennial flowering plant growing all over the world. Herbs of Gold Quercetin Complex provides 500mg of quercetin blended with bioflavonoids and vitamin C to support healthy immune system function. Quercetin for immune health It's easy to while away the winter inside but come spring and you'll likely want to head outdoors—particularly after a solid year of isolation and limited (if any) social contact . Advanced Milk Thistle, 120 gels. . Found inside – Page 108There are also rose hip bioflavonoids as well as citrus bioflavonoids such as catechin, hesperidin, rutin, quercetin, milk thistle seed extract, ginkgo extracts, pycnogenol and rice bran extract. antioxiDants: vital For Your HealtH A ... $19.99. This supplement is composed of four flavonoid compounds which include silibinin, isosilybin, silymarin, and silybin. Like other thistles, the plant protects itself with sharp thorns, which are memorable when brushed against. Milk thistle plant is native to the Mediterranean region and have been in use for over 2000 years. However, more research is needed on the effects of milk thistle on blood pressure. Our Milk Thistle is standardized to 80% silymarin, guaranteeing a high potency of the active silymarin nutrient. [11] This study noted enhancement of Doxorubicin cytotoxicity due to P-Gp inhibition, which has been noted in prostatic cells due to Silybinin[12] and noted elsewhere with Silybin[13] and the lack of changes to P-Gp protein content was replicated over 24 hours. Payment options are T/T, L/C, D/A, D/P, Western Union and Money Gram. eWorldTrade.com provides 104 products, Manufacturers and Suppliers from China, Cuba and India. Milk Thistle as a herb contains a variety of compounds (if eating the thistle or buying Silybum Marianum seeds whole), but most studies use an ethanolic extract with a high Silymarin component; this Silymarin component is mostly just 7 flavonolignans that are seen as unique to Milk Thistle Many studies assess 'Silymarin' collectively, which should be seen as a nondiscriminate mixture of the . Found inside – Page 118... B12 (methylcobalamin, sublingual fast‐dissolving tablet) Vitamin C (mineral ascorbates) Vitamin A (retinyl palmitate and beta‐carotene) Vitamin D3 (cholecalciferol) Betaine HCL Quercetin Milk thistle extract and N‐acetyl cysteine ... Quercetin Complex contains bioflavonoids, a group of plant pigments that give colour to many fruits and vegetables including, onions, apples, broccoli and berries. Kaempferol, quercetin, isorhamnetin, isoquercitrin, astragalin, rutin, and their 3‑rutinosides and 3‑glycosides are the flavonoids found in nettle. Clinical Summary. Known for its powerful antioxidant properties, helps support liver health, detoxification and waste elimination. Milk thistle (Silybum marianum L.) have been used for almost 2 000 years as a natural treatment for the liver diseases (Ding et al. Also, on days following anti-senokytic seems reasonable to hold anti-oxidants active . Milk thistle has been used for centuries to treat acute and chronic liver diseases and, even today, is one of the most widely used herbal medications. N-Acetyl-L-Cysteine is a precursor to glutathione, which is your body's "master detoxifier." Advanced Liver Support is manufactured in the USA from globally sourced ingredients by Formulation Technology, Inc. Silymarin is a medicinal extract of milk thistle (Silybum marianum), a member of the Compositae or daisy family. 現成功登及成功體驗，療程後可獲贈Mesoestetic修復精華及面霜禮品包一份(數量有限，送完即止), 色斑礙眼、皺紋明顯、臉部鬆弛，以上種種肌膚初老症狀點解決 ? [19], Milk Thistle is implicated in enhancing cellular protein synthesis, which may underlie therapeutic purposes of Milk Thistle in the liver. I asked him to use them on all days except for those when he receives chemo (gemcitabine and oxaliplatin) and for 2 days afterwards. #60025 50 ml 1 Liquid. Add to cart. Gaernt. Quercetin can also help stabilize the cells that release histamine in the body and thereby have an anti-inflammatory and antihistamine effect. Healthy Additions: Milk Thistle. This micronutrient is a metal and can cause toxicity if too much accumulates in the body. Contains Silymarin, Milk Thistle, Artichoke and Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Milk thistle is known for its anti-inflammatory and antioxidant properties. You can get Milk Thistle in bulk quantity. [18], One study in mouse adipocytes (MC3T3-G2/PA6) noted that Silybin did not inhibit insulin-induced phosphorylation of the receptor, nor the activation of Akt in response to insulin;[19][20] the insulin-induced glucose uptake, however, appears to be effectively abolished (not significantly different than medium without insulin) at 10uM concentration, with significance at 5uM[20] (although a later study using up to 40uM did not replicated the abolishment, but just noted concentration dependent reductions in glucose uptake. [22], NF-kB may also be implicated, as a mouse model of Non-alcoholic fatty liver disease (NAFLD) noted abnormal expression of NF-kB and its subsets (p50, p65) activity which was normalized with 20mg/kg Silybinin injections.[23]. 3. This complete manual features detailed examinations of the most popular and effective dietary supplements, nutrients, herbs, and other natural alternative remedies, their applications, their history, and their benefits. [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. It’s best to assess your red blood cell (RBC) copper levels prior to supplementing. Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, ... The main active substances occurring in milk thistle are flavonolignans, which. Keeps your liver and gut healthy and offers antioxidant protection. Milk Thistle: The active ingredient in Milk Thistle is silymarin which has long been recognized for its ability to benefit liver disorders, including hepatitis and cirrhosis, and protect the liver from poisons and toxins. Milk thistle is one of the most powerful supplements available today that helps detox the liver, protect the body from free radical damage, and reduce inflammation. Facts about Sylimarin. Usage of Milk Thistle as a galactogogue may be related to the Christian legend of how the Virgin Mary could only seek refuge for the birth of Jesus via a shelter in a bower formed from the thorny leaves of the milk thistle,[1] which seems to have begun intertwining of Milk Thistle with motherhood in general. High potency resveratrol is pretty pricey, so it’s not a bad idea to try other supplements before this one! 11 pages of results. Injections of isolated Silybinin to rats has resulted in increase polymerase I activity and subsequent protein synthesis[21] and enhanced DNA synthesis has been observed in rats with a partial hepatectomy (missing parts of the liver) but failed to be observed in healthy controls or hepatoma/neoplastic cells. Milk Thistle is native to the Mediterranean and is a member of the same family as sunflowers and daisies. If your dog is suffering from allergies or a stressed liver (liver disease), then milk thistle is the herb for him! Get a monthly report summarizing studies in the health categories that matter specifically to you. Vital Nutrients Aller-C combines Vitamin C, quercetin and bromelain, BioGenesis Resveratrol plus Flavonoids combines resveratrol with other flavonoids like green tea extract, pine bark extract and bromelain, Complementary Prescriptions Histamine Balance combines Vitamin C, Quercetin, Bromelain and Magnesium, Protocol for Life Balance Aller-All combines B6, B5, Vitamin C, Zinc, Quercetin and Stinging Nettles. NAC acetyl cysteine & NAC immune support, promotes healthy immune system. Found inside – Page 236... the purified extract from milk thistle, has shown protective effects against different types of acute and chronic ... It has been reported that quercetin is the major flavonoid found in foods and the average intake of quercetin ... The typical silymarin dosage used in most studies was ~420 mg/day divided into 2 or 3 doses. deleted_user 09/23/2010. Silymarin's primary constituents are the flavonolignan isomers silybins A and B, isosilybins A and B, silychristin (also known as silichristin), silydianin (also known as silidianin), and their flavonoid precursor, taxifolin. Milk Thistle (as well as Fenugreek) appears to be one of the herbs recommended as a Galactogogue to promote lactation in new mothers. A single-blind placebo controlled study that aimed to compare Silymarin, N-acetylcysteine, and Selenium to placebo in reducing lesion counts, found that after eight weeks of supplementation, there was a notable reduction in lesion count in all of the experimental groups, however, the reduction in lesion count was only statistically significant in the N-acetylcysteine and Silymarin groups. 20% glycyrrhizic acid) : 200 mg * Astragalus (Astragulus chinensis) root, dried extract, min. Important for immune health, Vitamin C is a strong antioxidant that also helps clear histamine from the blood by increasing DAO production. Sometimes it is better to see how you react to a single nutrient before trying them in conjunction with others. [27], Acne vulgaris is a chronic skin disease characterized by follicular hyperkeratinization,hormonally-mediated sebum overproduction, and chronic inflammation of the pilosebaceous unit. Milk Thistle (Silybum marianum) is a favorite among herbalists for its strong hepatoprotective properties that support liver function and protect the body against toxins.Powerful polyphenols found in Milk Thistle include Silymarin and Silybin, and these flavonoid compounds have been shown to benefit liver function and improve health. This is a professional level major reference work containing information, in A-Z format, on herb-drug, herb-supplement, herb -food and herb-laboratory test interactions; all of which is data referenced. Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. Quercetin, mainly present in the plant leaves, is a popular natural antioxidant (Abenavoli et al., 2018). [1] Silymarin is a standardized preparation extracted from the fruits (seeds) of milk thistle. [33] This study failed to report any Silymarin components in the breast milk when assessed, the composition of the breast milk did not appear to change, and the study did not appear to be funded by the producers of the supplement used (BIO-C).[33]. 100% vegetarian. Silymarin is a polyphenolic flavonoid derived from milk thistle. Polyphenols: Mechanisms of Action in Human Health and Disease, Second Edition describes the mechanisms of polyphenol antioxidant activities and their use in disease prevention. Found inside – Page 1393... artichoke ( Cynara scolymus ) leaf extract , and milk thistle ( Silybum marianum ) fruit extract . ... bromelain ( proteolytic enzymes ) , and quercetin Tai chi chuan Therapeutic touch Warm or cold compresses Yoga Heartburn ... For sure, milk thistle was first documented thousands of years ago, but where it actually got its biblical nickname, well, that we can't say for sure. [29]. Leave A Reply. Found inside – Page 60Quercetin is a very potent antioxidant, many hundreds of times more powerful than vitamin E. It can make a substantial contribution to Type A cancer-prevention strategies. Milk Thistle Like quercetin, milk thistle is an effective ... It derives its name Silybum (sometimes also sillybon) from the greek physician Pedanius Dioscorides (used just to refer to being an edible thistle[1]) and Marianum appears to come from a legend that the white veins running through the plant’s leaves (the 'Milk' aspect of Milk Thistle) were caused by a drop of the Virgin Mary’s milk. Milk thistle properties includes high amount of antioxidant, anti-inflammatory, and anti-viral. Milk thistle is a popular natural herb with a long history of use and an excellent safety profile. The Silymarin group supplemented 210 mg/day orally, for at least 8 weeks and saw a 53% reduction in total lesion counts. Skip to content. Milk Thistle Seed Extract. Quercetin scopes out free radicals, helping Alpha Lipoic Acid and Turmeric Root Extract to know what to get rid of. Found inside – Page 153Examples include grape seed extract, quercetin, milk thistle, green tea, and ginkgo biloba. It is important to consult with your health care provider for proper dosage and guidelines. Vitamin D: A number of studies have found a ... $19.99. 350 calories consumed, Khella extract in tincture form absorbs best to improve respiratory symptoms. Quercetin, mainly present in the plant leaves, is a popular natural antioxidant (Abenavoli et al., 2018). As always, check with a healthcare professional before beginning any supplement protocol. This page features 33 references. Well, I think my research is over for the time being!!! MT fruits contain a mixture of flavonolignans collectively known . Milk thistle (Silybum marianum) contains silymarin which is a mixture of flavonolignans, mainly silibinin (also known as silybin), as well as silycristine, silydianin, quercetin and taxifolin. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. [16], Silybinin (mixture) in predifferentiated 3T3-L1 adipocytes appears to concentration-dependently reduce differentiation and triglyceride accumulation with 5uM being significant (about 80% of control) and concentrations up to 30uM tested reducing triglyceride accumulation to about 40% of control;[17] a highly significant suppression of adipogenic markers was observed (PPARy, HSL, LPL, aP2, C/EBPα, and SREBP1c) which were thought to be downstream of an induction of insig-1 and insig-2 acutely (with no difference on the second day of incubation),[17] two proteins that regulate SREBP gene transcription and involved in adipogenesis. Silymarin is an extract of milk thistle seeds. I like this Vitamin C because it’s corn free. While fermented foods are high in histamine, taking a good quality probiotic to help balance the gut microbiome may be helpful for histamine intolerance. Now in the final part of this blog series, you’ll learn about helpful supplements for histamine intolerance and some of my favorite product picks! Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. N-A-C boosts the body's . Milk thistle is considered to be safe when used properly. Vitamin B6 (Pyridoxine; Pyridoxal 5′-Phosphate). Ingredients Quercetin has a wide range of health benefits. Examine.com and its Editors do not advocate nutritional supplementation over proper medical advice or treatment and this sentiment will never be expressed through pages hosted under Examine.com. Taking a supplement before the onset of cold . It gets its name from the milky-white liquid that runs off the leaves when they are crushed. [28] It is believed that the damaging of lipids in the skin via free radicals is responsible for the inflammatory component of acne. Found inside – Page 190... green tea Proanthocyanidins Oligomeric catechins Ginkgo, grape seeds, pine bark Flavones and flavonols Quercetin, kaempferol Ginkgo, ... flavonol glycosides (quercetin, quercetrin, rutin) Milk thistle [8] (Silybum marianum gaertn.) ... Probiotic. Milk thistle contains silibinin, a compound which helps decrease the release of inflammatory cytokines like histamine from mast cells. The antihistamine action of ascorbic acid. 0. Recent research has found that those who suffer from acne are unable to mitigate this damage efficiently because their antioxidant defense system is overwhelmed. to see the full set of research information and references for Milk thistle. What are the medicinal properties of Sylimarin? Milk Thistle Benefits. Found inside – Page 117Reduces derived from an old ulmaria ) methyl salicylate , quercetin , rutin , inflammation and strengthens and name for this ... Milk thistle Fruit , Phytochemicals : Apigenin , beta- Protects the liver from toxins and Also called Mary ... Found inside... quercetin, resveratrol, rutin, and silymarin (milk thistle seed). The strongest appear to be Scutellaria baicalensis, Oenothera paradoxa (evening primrose) oil, Paeonia lactiflora, quercetin, rutin, resveratrol, and silymarin. Quercetin also blocks histamine release from mast cells, thereby reducing allergy symptoms. Milk Thistle: Milk thistle contains silibinin, a compound which helps decrease the release of inflammatory cytokines like histamine from mast cells. Found inside – Page 32937.2.9 Other Herbal Preparations Other herbal medications, e.g., stinging nettle, milk thistle, gingko, extract of grape seed, quercetin, and Perilla frutescens, either show no or little evidence to support their use in allergic ... Found inside – Page 259... damage of DNA may be accomplished by administering alpha lipoic acid, curcumin, quercetin, milk thistle, and coenzyme Q-10. Ginkgo biloba, an herb known for its ability to reduce cognitive degeneration, would be helpful as well. This is an affiliate marketing marketplace. Silybin is the most active phytochemicals and is largely responsible for the claimed benefits of silymarin. I like this form of copper because it is chelated (meaning it is bound to an amino acid, specifically glycine), entering the digestive tract more easily for absorption. This book integrates eleven chapters that show the state of the art of diverse biological activity of the phenolic compounds, present in some crops or fruits. The dose may be too low to pick up any benefits, but risk/cost and side effects should be low. Quercetin also blocks histamine release from mast cells, thereby reducing allergy symptoms. This supplement is composed of four flavonoid compounds which include silibinin, isosilybin, silymarin, and silybin. This review focuses on the therapeutic promise of dihydroquercetin in major disease states such as cancer, c … Logic would have us believe this is an ancient, spiritually relevant plant. dietitians, physicians, and pharmacists. Milk Thistle Extract for promotion of healthy liver function. Silymarin is consists of three phytochemicals: silybin, silidianin and silicristin. Most milk thistle products are standardized to contain 70 - 80% of . If milk thistle is taken by someone using protease inhibitors or non-nukes, it has the potential to raise levels of these drugs, causing unpleasant or even dangerous side effects. Each member of our research team is required to have no . (Gillessen 2020) The World Health Organization (WHO) recognized it as an official hepatoprotective medicine in 1970. Resveratrol is an antioxidant that protects the heart. Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com. The team includes nutrition researchers, registered possessing pronounced membrane-stabilizing action. Compounds that are subject to P-Gp may have their bioavailability enhanced when this protein is inhibited secondary to less efflux. milk thistle fruits also contains quercetin . This is an affiliate marketing marketplace. https://examine.com/supplements/milk-thistle/, © 2011–2021 Examine.com Inc. | Examine™ is a trademark of Examine.com Inc. | Privacy | Terms of Service | Disclaimer | About Us | Contact Us. [3] The exact mechanism is unknown, but has been thought to be due to RNA polymerase I and ribosomal RNA activation somehow. deleted_user 09/23/2010. [1], It has a history of usage in the Middle East and Europe, and extends back to Roman and Greek usage (from where it was initially named); its most common recommendations if for a multitude of liver disorders including gallbladder disorders, including hepatitis, cirrhosis and jaundice, and to protect the liver against poisoning from chemical and environmental toxins, including snakebites, insect stings, mushroom poisoning and alcohol. Pet parents do need to be careful if their dogs are on medications that are metabolized through a certain pathway in the liver called the P450 pathway. Click here - Firstly, milk thistle supports liver detoxification, and as candida does release a lot toxins it means that you a helping your liver processes these toxins. Our evidence-based analysis on milk thistle features 33 unique references to scientific papers. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. Milk Thistle helps: lower high cholesterol levels by lowering inflammation Quercetin supports a healthy inflammatory response in the liver. Quercetin: Quercetin is a flavonoid . [22] This was not related to antioxidant properties (N-Acetylcysteine failed to mimic the protective effects) but Silymarin preserved activation of Akt (normally reduced during lipotoxicity, its preservation enhances cell survival). . Become an Examine Member to get access to all of the latest nutrition research: Milk Thistle (Silybum Marianum of the family Asteraceae) is a medicinal thistle that has been used in traditional medicines. This collection of research and review articles covers the most recent advances in the use of plant polyphenols, ranging from their biological properties and possible functions as medicines, the importance of traditional medicines as a ... Ideally, the silybin content should also be mentioned and account for ~40% (the higher the better). Milk thistle extract (Silybum marianum), also known as St. Mary's thistle, is an herbal supplement primarily used to support liver function in horses.Milk thistle seeds and leaves contain many bioactive compounds, collectively referred to as silymarin. 80% silymarin : 210 mg * Licorice (Glycyrrhiza glabra) root, dried extract, min. Silymarin (mixture) at 50uM has been shown to accumulate daunomycin (substrate of P-Gp) in cells expressing P-Gp with no effect on cells without P-Gp, this study noted accumulation of 445+/-12%, which was similar to phloretin and slightly less than Morin (from Morus Alba) and Biochanin A. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. Found in the skin of red grapes as well as blueberries, resveratrol is an polyphenol antioxidant that helps quench free radicals and prevents cellular damage. Below is a short list of some other medications that are processed through the CYP3A4 enzyme. Yep, that weedy looking plant with purple flowers is a detox powerhouse for dogs! [9] When assessing the Silibinin content (isomeric mixture), 50uM of Silybinin can reduce superoxide production by Xanthine Oxidase 20%, still confers mixed inhibition, and appeared to be of comparable potency to allopurinol in vitro yet conferred less inhibition than both Quercetin and Luteolin (all at the same concentrations).[10]. In Part 1, I discussed the basics of histamine intolerance, its hallmark signs and symptoms, and some testing options to help histamine intolerance. Found insideCellgevity Healing Cocktail Properties • RiboCeineTM; Alpha Lipoic Acid; Broccoli Seed Extract; Turmeric Root Extract • Resveratrol; Grape Seed Extract; Quercetin; Milk Thistle; Vitamin C • Selenomethionine; Cordyceps; Black Pepper; ... Provides information on scientific and common names, characteristics, active compounds, clinical effects, indications, usage, clinical research, precautions, interactions, and dosage for over seven hundred herbs. Milk Thistle contains a group of flavonoids collectively called . Found inside – Page 1864... 1773, 1806 pine bark extract, 901 quercetin, 773 resveratrol, 901 Silybum marianum (milk thistle), 1027 I/accinium myrtillus (bilberry), 1083 antioxidants (Continued) procyanidolic oligomers (procyanidins), 9964997, 996b quercetin, ... Although grapes and blueberries are high histamine foods, resveratrol intake has been linked to decreased incidence of mast cell disorders by inhibiting tumor necrosis factor and interleukins, proinflammatory compounds. Introduction. Found insideWhen it comes to nutrients that prevent or treat allergies, it's hard to beat quercetin. ... Additionally, some medicinal herbs are excellent sources of quercetin, including milk thistle, olive leaf, bilberry, elder, licorice, primrose, ... In, Oksaharju, A., Kankainen, M., Kekkonen, R. A., Lindstedt, K. A., Kovanen, P. T., Korpela, R., & Miettinen, M. (2011). Milk thistle in liver diseases: past, present, future, Complementary therapies for treating alcoholism First Annual meeting by Complementary Medicine Research Group of the Italian Society for Alcohol Studies-May 5, 2006, Florence, Italy, Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine, Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies, Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum), Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, Isolated from Silybum marianum (milk thistle), Membranes and the setting of energy demand, Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts, Inhibition of xanthine oxidase by purpurogallin and silymarin group, Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin, Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport, Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis, The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein, Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control, Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans, Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway, Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins, Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells, Biochemical effects of the flavonolignane silibinin on RNA, protein and DNA synthesis in rat livers, Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation, Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis, An updated systematic review with meta-analysis for the clinical evidence of silymarin, Hepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in mice, Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice, Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants, Effects of Oral Antioxidants on Lesion Counts Associated with Oxidative Stress and Inflammation in Patients with Papulopustular Acne, The use of galactogogues in the breastfeeding mother, The use of botanicals during pregnancy and lactation, Clinical efficacy, safety and tolerability of BIO-C (micronized Silymarin) as a galactagogue, https://examine.com/supplements/milk-thistle/.
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